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TargetPlasminogen
LigandBDBM50017894
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1364437
Ki 0.000000±n/a nM
Citation Goswami RMukherjee SGhadiyaram CWohlfahrt GSistla RKNagaraj JSatyam LKSubbarao KPalakurthy RKGopinath SKrishnamurthy NRIkonen TMoilanen ASubramanya HSKallio PRamachandra M Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy. Bioorg Med Chem 22:3187-203 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Plasminogen
Name:Plasminogen
Synonyms:Activation peptide | Angiostatin | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:Enzyme
Mol. Mass.:90579.18
Organism:Homo sapiens (Human)
Description:n/a
Residue:810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT
CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN
GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE
CEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRE
LRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWS
AQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTE
QLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAG
LTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED
CMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGG
PWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRT
RFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE
PTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQ
LPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSW
GLGCARPNKPGVYVRVSRFVTWIEGVMRNN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50017894
n/a
NameBDBM50017894
Synonyms:CHEMBL3289040
TypeSmall organic molecule
Emp. Form.C25H28N6O3
Mol. Mass.460.5282
SMILESN[C@H]1CC[C@@H](CC1)NC(=O)c1cc(Oc2ccc(cc2)C(N)=N)cc(Oc2ccc(N)nc2)c1 |r,wU:1.0,wD:4.7,(21.6,-9.88,;20.27,-9.11,;18.94,-9.88,;17.6,-9.11,;17.6,-7.57,;18.94,-6.8,;20.27,-7.57,;16.27,-6.8,;14.94,-7.57,;14.94,-9.11,;13.6,-6.8,;13.6,-5.26,;12.27,-4.49,;12.27,-2.95,;13.6,-2.18,;13.6,-.64,;14.94,.13,;16.27,-.64,;16.27,-2.18,;14.94,-2.95,;17.6,.13,;18.94,-.64,;17.6,1.67,;10.94,-5.26,;10.94,-6.8,;9.6,-7.57,;8.27,-6.8,;6.93,-7.57,;5.6,-6.8,;5.6,-5.26,;4.27,-4.49,;6.93,-4.49,;8.27,-5.26,;12.27,-7.57,)|
Structure
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