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TargetPlasminogen
LigandBDBM50017933
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1364437
Ki 0.000000±n/a nM
Citation Goswami RMukherjee SGhadiyaram CWohlfahrt GSistla RKNagaraj JSatyam LKSubbarao KPalakurthy RKGopinath SKrishnamurthy NRIkonen TMoilanen ASubramanya HSKallio PRamachandra M Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy. Bioorg Med Chem 22:3187-203 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Plasminogen
Name:Plasminogen
Synonyms:Activation peptide | Angiostatin | Plasmin | Plasmin heavy chain A | Plasmin heavy chain A, short form | Plasmin light chain B
Type:Enzyme
Mol. Mass.:90579.18
Organism:Homo sapiens (Human)
Description:n/a
Residue:810
Sequence:
MEHKEVVLLLLLFLKSGQGEPLDDYVNTQGASLFSVTKKQLGAGSIEECAAKCEEDEEFT
CRAFQYHSKEQQCVIMAENRKSSIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKN
GITCQKWSSTSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILE
CEEECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRE
LRPWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWS
AQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVSTE
QLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAG
LTMNYCRNPDADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED
CMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGG
PWCYTTNPRKLYDYCDVPQCAAPSFDCGKPQVEPKKCPGRVVGGCVAHPHSWPWQVSLRT
RFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLE
PTRKDIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFGAGLLKEAQ
LPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSW
GLGCARPNKPGVYVRVSRFVTWIEGVMRNN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50017933
n/a
NameBDBM50017933
Synonyms:CHEMBL3289299
TypeSmall organic molecule
Emp. Form.C27H32N4O3
Mol. Mass.460.568
SMILESNCc1ccc(Oc2cc(Oc3ccc(CN)cc3)cc(c2)C(=O)N[C@H]2CC[C@H](N)CC2)cc1 |r,wU:25.26,wD:28.30,(12.19,1.09,;12.19,-.45,;10.85,-1.22,;9.52,-.45,;8.19,-1.22,;8.19,-2.76,;6.85,-3.53,;6.85,-5.07,;5.52,-5.84,;5.52,-7.38,;4.19,-8.15,;2.85,-7.38,;1.52,-8.15,;.18,-7.38,;.18,-5.84,;-1.15,-5.07,;-2.48,-5.84,;1.52,-5.07,;2.85,-5.84,;6.85,-8.15,;8.19,-7.38,;8.19,-5.84,;9.52,-8.15,;9.52,-9.69,;10.85,-7.38,;12.19,-8.15,;13.52,-7.38,;14.86,-8.15,;14.86,-9.69,;16.19,-10.46,;13.52,-10.46,;12.19,-9.69,;9.52,-3.53,;10.85,-2.76,)|
Structure
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