Reaction Details |
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Target | Retinoic acid receptor RXR-alpha |
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Ligand | BDBM31892 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1365627 (CHEMBL3297474) |
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Kd | 14±n/a nM |
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Citation | Atigadda, VR; Xia, G; Desphande, A; Boerma, LJ; Lobo-Ruppert, S; Grubbs, CJ; Smith, CD; Brouillette, WJ; Muccio, DD Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J Med Chem57:5370-80 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor RXR-alpha |
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Name: | Retinoic acid receptor RXR-alpha |
Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
Type: | PROTEIN |
Mol. Mass.: | 50820.38 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1456363 |
Residue: | 462 |
Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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BDBM31892 |
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n/a |
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Name | BDBM31892 |
Synonyms: | 9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin | alitretinoin |
Type | Small organic molecule |
Emp. Form. | C20H28O2 |
Mol. Mass. | 300.4351 |
SMILES | C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O |c:4| |
Structure |
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