Reaction Details |
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Target | Retinoic acid receptor RXR-alpha |
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Ligand | BDBM31892 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1365631 (CHEMBL3297478) |
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EC50 | 110±n/a nM |
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Citation | Atigadda, VR; Xia, G; Desphande, A; Boerma, LJ; Lobo-Ruppert, S; Grubbs, CJ; Smith, CD; Brouillette, WJ; Muccio, DD Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. J Med Chem57:5370-80 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Retinoic acid receptor RXR-alpha |
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Name: | Retinoic acid receptor RXR-alpha |
Synonyms: | NR2B Channel Blocker | Nr2b1 | RXRA_RAT | Retinoic acid receptor RXR-alpha | Retinoid X receptor alpha | Rxra |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 51273.78 |
Organism: | RAT |
Description: | NR2B Channel Blocker 0 RAT::Q05343 |
Residue: | 467 |
Sequence: | MDTKHFLPLDFSTQVNSSSLSSPTGRGSMAAPSLHPSLGPGLGSPLGSPGQLHSPISTLS
SPINGMGPPFSVISSPMGPHSMSVPTTPTLGFETGSPQLNSPMNPVSSSEDIKPPLGLNG
VLKVPAHPSGNMSSFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNK
DCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVEKI
LEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLD
DQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVS
KMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRF
AKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQTT
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BDBM31892 |
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n/a |
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Name | BDBM31892 |
Synonyms: | 9-cis retinoic acid | 9C-RA | CHEMBL705 | Panretin | alitretinoin |
Type | Small organic molecule |
Emp. Form. | C20H28O2 |
Mol. Mass. | 300.4351 |
SMILES | C\C(\C=C\C1=C(C)CCCC1(C)C)=C\C=C\C(\C)=C\C(O)=O |c:4| |
Structure |
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