| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenosylhomocysteinase |
|---|
| Ligand | BDBM50006215 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1362082 (CHEMBL3294635) |
|---|
| IC50 | 4125±n/a nM |
|---|
| Citation |  Converso, A; Hartingh, T; Fraley, ME; Garbaccio, RM; Hartman, GD; Huang, SY; Majercak, JM; McCampbell, A; Na, SJ; Ray, WJ; Savage, MJ; Wolffe, C; Yeh, S; Yu, Y; White, R; Zhang, R Adenosine analogue inhibitors of S-adenosylhomocysteine hydrolase. Bioorg Med Chem Lett24:2737-40 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenosylhomocysteinase |
|---|
| Name: | Adenosylhomocysteinase |
|---|
| Synonyms: | AHCY | Adenosylhomocysteinase | SAHH | SAHH_HUMAN |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 47714.06 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1507791 |
|---|
| Residue: | 432 |
|---|
| Sequence: | MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVET
AVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYF
KDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINV
NDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVI
ITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIG
HFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSN
SFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMS
CDGPFKPDHYRY
|
|
|
|---|
| BDBM50006215 |
|---|
| n/a |
|---|
| Name | BDBM50006215 |
|---|
| Synonyms: | (1'R,2'S,3'R)-9-(2',3'-dihydroxycyclopent-4'-enyl)adenine | (1S,2R,5R)-5-(6-Amino-purin-9-yl)-cyclopent-3-ene-1,2-diol | 5-(6-Amino-purin-9-yl)-cyclopent-3-ene-1,2-diol | CHEMBL299961 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H11N5O2 |
|---|
| Mol. Mass. | 233.2266 |
|---|
| SMILES | Nc1ncnc2n(cnc12)[C@@H]1C=C[C@@H](O)[C@H]1O |c:13| |
|---|
| Structure | 
|
|---|
Search and Browse
