| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-1 adrenergic receptor |
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| Ligand | BDBM50018598 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1362119 (CHEMBL3294891) |
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| Ki | <10000±n/a nM |
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| Citation |  Jacobsen, JR; Aggen, JB; Church, TJ; Klein, U; Pfeiffer, JW; Pulido-Rios, TM; Thomas, GR; Yu, C; Moran, EJ Multivalent design of long-actingß(2)-adrenoceptor agonists incorporating biarylamines. Bioorg Med Chem Lett24:2625-30 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-1 adrenergic receptor |
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| Name: | Beta-1 adrenergic receptor |
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| Synonyms: | ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | adrenergic Beta1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 51338.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08588 |
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| Residue: | 477 |
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| Sequence: | MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAG
MGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVV
WGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVC
TVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIM
AFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAP
LANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFV
FFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAARRRHATHGDRPRASGCLARPGP
PPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
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| BDBM50018598 |
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| n/a |
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| Name | BDBM50018598 |
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| Synonyms: | CHEMBL3290979 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H37N3O4 |
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| Mol. Mass. | 491.6218 |
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| SMILES | COc1ccc(CN2CCN(CC2)c2ccc(CCNCC(O)c3ccc(O)c(CO)c3)cc2)cc1 |
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| Structure | 
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