Reaction Details |
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Target | Carbonic anhydrase 12 |
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Ligand | BDBM50018641 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1362448 (CHEMBL3292804) |
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IC50 | 376±n/a nM |
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Citation | Tauro, M; Loiodice, F; Ceruso, M; Supuran, CT; Tortorella, P Dual carbonic anhydrase/matrix metalloproteinase inhibitors incorporating bisphosphonic acid moieties targeting bone tumors. Bioorg Med Chem Lett24:2617-20 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 12 |
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Name: | Carbonic anhydrase 12 |
Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
Type: | Enzyme |
Mol. Mass.: | 39456.00 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 354 |
Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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BDBM50018641 |
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n/a |
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Name | BDBM50018641 |
Synonyms: | CHEMBL3291006 |
Type | Small organic molecule |
Emp. Form. | C8H13NO9P2S |
Mol. Mass. | 361.203 |
SMILES | COc1ccc(cc1)S(=O)(=O)NC(P(O)(O)=O)P(O)(O)=O |
Structure |
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