Reaction Details |
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Target | Amine oxidase [flavin-containing] A |
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Ligand | BDBM50018671 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1362470 (CHEMBL3293071) |
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IC50 | 2300±n/a nM |
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Citation | Wang, L; Esteban, G; Ojima, M; Bautista-Aguilera, OM; Inokuchi, T; Moraleda, I; Iriepa, I; Samadi, A; Youdim, MB; Romero, A; Soriano, E; Herrero, R; Fernández Fernández, AP; Ricardo-Martínez-Murillo, na; Marco-Contelles, J; Unzeta, M Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease. Eur J Med Chem80:543-61 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Amine oxidase [flavin-containing] A |
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Name: | Amine oxidase [flavin-containing] A |
Synonyms: | AOFA_RAT | Amine oxidase (flavin-containing) A | Amine oxidase [flavin-containing] A | Maoa | Monoamine Oxidase Type A (MAO-A) | Monoamine oxidase | Monoamine oxidase A (MAO-A) | Monoamine oxidase A (rMAO-A) | Monoamine oxidase type A (MAOA) |
Type: | Enzyme |
Mol. Mass.: | 59515.21 |
Organism: | Rattus norvegicus (rat) |
Description: | n/a |
Residue: | 526 |
Sequence: | MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHV
KWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLA
YLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNI
NVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKL
SSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPM
GAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADR
QAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKD
VPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
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BDBM50018671 |
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n/a |
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Name | BDBM50018671 |
Synonyms: | CHEMBL3291019 |
Type | Small organic molecule |
Emp. Form. | C29H32N4O |
Mol. Mass. | 452.5906 |
SMILES | Oc1ccc(CN(CC#C)C(CCC2CCN(Cc3ccccc3)CC2)C#N)c2cccnc12 |
Structure |
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