Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
Target11-beta-hydroxysteroid dehydrogenase 1
LigandBDBM50018794
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1362858 (CHEMBL3295808)
IC50 16±n/a nM
Citation Gillespie, PPietranico-Cole, SMyers, MBilotta, JAConde-Knape, KFotouhi, NGoodnow, RAGuertin, KRHamilton, MMHaynes, NELiu, BQi, LRen, YScott, NRSo, SSSpence, CTaub, RThakkar, KTilley, JWZwingelstein, C Discovery of camphor-derived pyrazolones as 11ß-hydroxysteroid dehydrogenase type 1 inhibitors. Bioorg Med Chem Lett24:2707-11 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-hydroxysteroid dehydrogenase 1
Name:11-beta-hydroxysteroid dehydrogenase 1
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1
Type:Enzyme
Mol. Mass.:31889.48
Organism:Rattus norvegicus (rat)
Description:P16232
Residue:288
Sequence:
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50018794
n/a
NameBDBM50018794
Synonyms:CHEMBL3291340
TypeSmall organic molecule
Emp. Form.C24H26N2O
Mol. Mass.358.476
SMILES[H][C@@]12CC[C@@](C)(c3c1c(=O)n(-c1ccccc1)n3Cc1ccccc1)C2(C)C |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: