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Target11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)
LigandBDBM50018803
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1362858
IC50 21±n/a nM
Citation Gillespie PPietranico-Cole SMyers MBilotta JAConde-Knape KFotouhi NGoodnow RAGuertin KRHamilton MMHaynes NELiu BQi LRen YScott NRSo SSSpence CTaub RThakkar KTilley JWZwingelstein C Discovery of camphor-derived pyrazolones as 11-hydroxysteroid dehydrogenase type 1 inhibitors. Bioorg Med Chem Lett 24:2707-11 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)
Name:11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)
Synonyms:11-DH | 11-beta-HSD1 | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1)
Type:Enzyme
Mol. Mass.:31889.48
Organism:Rattus norvegicus (rat)
Description:P16232
Residue:288
Sequence:
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLT
ARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQT
TMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYS
ASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALE
IIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
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  Blast E-value cutoff:
BDBM50018803
n/a
NameBDBM50018803
Synonyms:CHEMBL3291358
TypeSmall organic molecule
Emp. Form.C26H30N2O
Mol. Mass.386.5292
SMILES[H][C@@]12CC[C@@](C)(c3c1c(=O)n(Cc1cccc(c1)-c1ccccc1C)n3C)C2(C)C |r|
Structure
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