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TargetProstaglandin D2 receptor 2
LigandBDBM50018898
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1364476 (CHEMBL3295024)
IC50 8.0±n/a nM
Citation Johnson, MGLiu, JJLi, ARvan Lengerich, BWang, SMedina, JCCollins, TLDanao, JSeitz, LWillee, AD'Souza, WBudelsky, ALFan, PWWong, SG Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP. Bioorg Med Chem Lett24:2877-80 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor 2
Name:Prostaglandin D2 receptor 2
Synonyms:CD_antigen=CD294 | CRTH2 | Chemoattractant Receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) | Chemoattractant receptor-homologous molecule expressed on Th2 cells | Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) | DL1R | G protein-coupled receptor 44 | G-protein coupled receptor 44 | GPR44 | PD2R2_HUMAN | PTGDR2 | Prostaglandin D2 | Prostaglandin D2 receptor 2 | Prostaglandin D2 receptor 2 (PGD2)
Type:Enzyme
Mol. Mass.:43295.45
Organism:Homo sapiens (Human)
Description:Q9Y5Y4
Residue:395
Sequence:
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCR
MRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGF
LLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRI
MCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRR
PGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVAN
PVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRP
EEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
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  Blast E-value cutoff:
BDBM50018898
n/a
NameBDBM50018898
Synonyms:CHEMBL3287082
TypeSmall organic molecule
Emp. Form.C26H22Cl2N2O6S
Mol. Mass.561.434
SMILESCOc1cc(CC(O)=O)ccc1Oc1ccc2[nH]c(cc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl)C1CC1
Structure
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