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TargetProstaglandin D2 receptor
LigandBDBM50018897
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1364478 (CHEMBL3295026)
IC50 9.0±n/a nM
Citation Johnson, MGLiu, JJLi, ARvan Lengerich, BWang, SMedina, JCCollins, TLDanao, JSeitz, LWillee, AD'Souza, WBudelsky, ALFan, PWWong, SG Solving time-dependent CYP3A4 inhibition for a series of indole-phenylacetic acid dual antagonists of the PGD(2) receptors CRTH2 and DP. Bioorg Med Chem Lett24:2877-80 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin D2 receptor
Name:Prostaglandin D2 receptor
Synonyms:PD2R_HUMAN | PTGDR | Prostaglandin D2 | Prostaglandin D2 receptor | Prostanoid DP receptor
Type:Enzyme
Mol. Mass.:40288.87
Organism:Homo sapiens (Human)
Description:Q13258
Residue:359
Sequence:
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSV
FYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSST
LQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPG
TWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCT
RDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTS
EEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50018897
n/a
NameBDBM50018897
Synonyms:CHEMBL3287081
TypeSmall organic molecule
Emp. Form.C24H20Cl2N2O6S
Mol. Mass.535.396
SMILESCOc1cc(CC(O)=O)ccc1Oc1ccc2n(C)ccc2c1NS(=O)(=O)c1ccc(Cl)cc1Cl
Structure
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