| Reaction Details |
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 | Report a problem with these data |
| Target | Acrosin |
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| Ligand | BDBM50018995 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1365286 (CHEMBL3292380) |
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| IC50 | 20500±n/a nM |
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| Citation |  Zhao, J; Tian, W; Qi, J; Lv, D; Liu, Y; Jiang, Y; Dong, G; Chen, Q; Zhou, Y; Zhu, J; Wang, H; Sheng, C; Lv, J Design and synthesis of phenylisoxazole derivatives as novel human acrosin inhibitors. Bioorg Med Chem Lett24:2802-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acrosin |
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| Name: | Acrosin |
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| Synonyms: | ACR | ACRO_HUMAN | ACRS |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45865.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1365286 |
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| Residue: | 421 |
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| Sequence: | MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSL
QIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPL
QERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVA
GWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDS
GGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSA
TPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASP
LPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTST
S
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| BDBM50018995 |
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| n/a |
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| Name | BDBM50018995 |
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| Synonyms: | CHEMBL3287465 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15ClFN5O2 |
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| Mol. Mass. | 375.785 |
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| SMILES | Cl.NC(=N)Nc1ccc(cc1)-c1cc(no1)C(=O)Nc1ccc(F)cc1 |
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| Structure | 
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