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TargetP2Y purinoceptor 12
LigandBDBM50439277
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1361115 (CHEMBL3291830)
IC50 9.0±n/a nM
Citation Giordanetto, FBach, PZetterberg, FAntonsson, TBylund, RJohansson, JSellén, MBrown, DHideståhl, LBerntsson, PHovdal, DZachrisson, HBjörkman, JAvan Giezen, JJ Optimization of ketone-based P2Y(12) receptor antagonists as antithrombotic agents: pharmacodynamics and receptor kinetics considerations. Bioorg Med Chem Lett24:2963-8 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2Y purinoceptor 12
Name:P2Y purinoceptor 12
Synonyms:ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999
Type:Enzyme
Mol. Mass.:39458.48
Organism:Homo sapiens (Human)
Description:Q9H244
Residue:342
Sequence:
MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50439277
n/a
NameBDBM50439277
Synonyms:CHEMBL2419490
TypeSmall organic molecule
Emp. Form.C23H26N4O5S
Mol. Mass.470.541
SMILESCCOC(=O)c1cc(C#N)c(nc1C)N1CCC(CC1)C(=O)NS(=O)(=O)Cc1ccccc1
Structure
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