Ki Summary

Reaction Details

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Target

Neurotensin receptor type 2

Ligand

BDBM50019420

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_1364517 (CHEMBL3295314)

622±n/a nM

Citation

Thomas, JB; Giddings, AM; Wiethe, RW; Olepu, S; Warner, KR; Sarret, P; Gendron, L; Longpre, JM; Zhang, Y; Runyon, SP; Gilmour, BP Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound. J Med Chem57:5318-32 (2014) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Neurotensin receptor type 2

Name:

Neurotensin receptor type 2

Synonyms:

Type:

PROTEIN

Mol. Mass.:

46280.50

Organism:

Rattus norvegicus

Description:

ChEMBL_1466615

Residue:

416

Sequence:

METSSPWPPRPSPSAGLSLEARLGVDTRLWAKVLFTALYSLIFAFGTAGNALSVHVVLKA
RAGRPGRLRYHVLSLALSALLLLLVSMPMELYNFVWSHYPWVFGDLGCRGYYFVRELCAY
ATVLSVASLSAERCLAVCQPLRARRLLTPRRTRRLLSLVWVASLGLALPMAVIMGQKHEV
ESADGEPEPASRVCTVLVSRATLQVFIQVNVLVSFALPLALTAFLNGITVNHLMALYSQV
PSASAQVSSIPSRLELLSEEGLLGFITWRKTLSLGVQASLVRHKDASQIRSLQHSAQVLR
AIVAVYVICWLPYHARRLMYCYIPDDGWTNELYDFYHYFYMVTNTLFYVSSAVTPILYNA
VSSSFRKLFLESLGSLCGEQHSLVPLPQEAPESTTSTYSFRLWGSPRNPSLGEIQV

BDBM50019420

n/a

Name

BDBM50019420

Synonyms:

CHEMBL3290104

Type

Small organic molecule

Emp. Form.

C26H28FN3O5

Mol. Mass.

481.516

SMILES

COc1cccc(OC)c1-c1cc(nn1-c1ccc(F)cc1)C(=O)N[C@@H](C1CCCCC1)C(O)=O |r,wU:25.28,(19.31,-17.83,;19.94,-16.43,;21.47,-16.26,;22.38,-17.51,;23.91,-17.35,;24.53,-15.94,;23.63,-14.7,;24.25,-13.29,;25.79,-13.13,;22.1,-14.86,;20.92,-13.24,;21.4,-11.77,;20.15,-10.87,;18.9,-11.77,;19.38,-13.24,;18.47,-14.48,;19.1,-15.89,;18.2,-17.14,;16.66,-16.98,;15.76,-18.22,;16.04,-15.57,;16.94,-14.32,;20.15,-9.33,;21.48,-8.56,;18.82,-8.56,;18.82,-7.02,;17.48,-6.25,;16.15,-7.02,;14.82,-6.25,;14.82,-4.71,;16.15,-3.94,;17.48,-4.71,;20.15,-6.25,;21.48,-7.02,;20.15,-4.71,)|

Structure