| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 2A |
|---|
| Ligand | BDBM50342538 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1361183 (CHEMBL3292157) |
|---|
| EC50 | 3400±n/a nM |
|---|
| Citation |  Storer, RI; Brennan, PE; Brown, AD; Bungay, PJ; Conlon, KM; Corbett, MS; DePianta, RP; Fish, PV; Heifetz, A; Ho, DK; Jessiman, AS; McMurray, G; de Oliveira, CA; Roberts, LR; Root, JA; Shanmugasundaram, V; Shapiro, MJ; Skerten, M; Westbrook, D; Wheeler, S; Whitlock, GA; Wright, J Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors. J Med Chem57:5258-69 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 5-hydroxytryptamine receptor 2A |
|---|
| Name: | 5-hydroxytryptamine receptor 2A |
|---|
| Synonyms: | 5-HTR2A | 5HT2A_CANLF | HTR2A |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52384.55 |
|---|
| Organism: | Canis familiaris |
|---|
| Description: | ChEMBL_1361183 |
|---|
| Residue: | 470 |
|---|
| Sequence: | MDVLFEDNAPLSPTTSSLMPSNGDPRLYGNDLNAGDANTSDAFNWTVDAENRTNLSCEGC
LSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIAD
MLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNP
IHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSF
VSFFIPLTIMVITYFLTIKSLQKEATLCVSDPGTRAKLASFSFLPQSSLSSEKLFQRSIH
REPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDIIGAL
LNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKS
SQLQMGQKKNSKKDAKSTDNDYSMVALGKQHSEDAPTDNINTVNEKVSCV
|
|
|
|---|
| BDBM50342538 |
|---|
| n/a |
|---|
| Name | BDBM50342538 |
|---|
| Synonyms: | 2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepine | CHEMBL1770373 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H17N3 |
|---|
| Mol. Mass. | 239.3156 |
|---|
| SMILES | C(c1ccccc1)c1ncc2CCNCCc2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
