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Target5-hydroxytryptamine receptor 2B
LigandBDBM50342538
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1361181 (CHEMBL3292155)
EC50>10000±n/a nM
Citation Storer, RIBrennan, PEBrown, ADBungay, PJConlon, KMCorbett, MSDePianta, RPFish, PVHeifetz, AHo, DKJessiman, ASMcMurray, Gde Oliveira, CARoberts, LRRoot, JAShanmugasundaram, VShapiro, MJSkerten, MWestbrook, DWheeler, SWhitlock, GAWright, J Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT2C) receptor agonists with exquisite functional selectivity over 5-HT2A and 5-HT2B receptors. J Med Chem57:5258-69 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 2B
Name:5-hydroxytryptamine receptor 2B
Synonyms:5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:54312.47
Organism:Homo sapiens (Human)
Description:Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
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BDBM50342538
n/a
NameBDBM50342538
Synonyms:2-benzyl-6,7,8,9-tetrahydro-5H-pyrimido[5,4-d]azepine | CHEMBL1770373
TypeSmall organic molecule
Emp. Form.C15H17N3
Mol. Mass.239.3156
SMILESC(c1ccccc1)c1ncc2CCNCCc2n1
Structure
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