| Reaction Details |
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 | Report a problem with these data |
| Target | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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| Ligand | BDBM50019859 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1361547 (CHEMBL3294871) |
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| Kd | 16±n/a nM |
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| Citation |  Zimmermann, G; Schultz-Fademrecht, C; Küchler, P; Murarka, S; Ismail, S; Triola, G; Nussbaumer, P; Wittinghofer, A; Waldmann, H Structure guided design and kinetic analysis of highly potent benzimidazole inhibitors targeting the PDEd prenyl binding site. J Med Chem57:5435-48 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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| Name: | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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| Synonyms: | 3',5'-cyclic phosphodiesterase | GMP-PDE delta | PDE6D | PDE6D_HUMAN | PDED | Protein p17 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 17418.30 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105761 |
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| Residue: | 150 |
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| Sequence: | MSAKDERAREILRGFKLNWMNLRDAETGKILWQGTEDLSVPGVEHEARVPKKILKCKAVS
RELNFSSTEQMEKFRLEQKVYFKGQCLEEWFFEFGFVIPNSTNTWQSLIEAAPESQMMPA
SVLTGNVIIETKFFDDDLLVSTSRVRLFYV
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| BDBM50019859 |
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| n/a |
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| Name | BDBM50019859 |
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| Synonyms: | CHEMBL3286923 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H42FN3O5 |
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| Mol. Mass. | 627.7449 |
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| SMILES | CC(C)c1c(C(=O)Nc2ccccc2)c(c(-c2ccc(F)cc2)n1CC[C@@H](O)C[C@@H](O)CC(=O)N1CCOCC1)-c1ccccc1 |r| |
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| Structure | 
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