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TargetIntermediate conductance calcium-activated potassium channel protein 4
LigandBDBM50019903
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1361891
IC50 48±n/a nM
Citation Blass B Fused Thiazin-3-ones as KCa3.1 Inhibitors. ACS Med Chem Lett 5:460-1 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Intermediate conductance calcium-activated potassium channel protein 4
Name:Intermediate conductance calcium-activated potassium channel protein 4
Synonyms:IK1 | IKCa1 | KCa4 | Putative Gardos channel | SK4
Type:PROTEIN
Mol. Mass.:47723.22
Organism:Homo sapiens (Human)
Description:ChEMBL_1361891
Residue:427
Sequence:
MGGDLVLGLGALRRRKRLLEQEKSLAGWALVLAGTGIGLMVLHAEMLWFGGCSWALYLFL
VKCTISISTFLLLCLIVAFHAKEVQLFMTDNGLRDWRVALTGRQAAQIVLELVVCGLHPA
PVRGPPCVQDLGAPLTSPQPWPGFLGQGEALLSLAMLLRLYLVPRAVLLRSGVLLNASYR
SIGALNQVRFRHWFVAKLYMNTHPGRLLLGLTLGLWLTTAWVLSVAERQAVNATGHLSDT
LWLIPITFLTIGYGDVVPGTMWGKIVCLCTGVMGVCCTALLVAVVARKLEFNKAEKHVHN
FMMDIQYTKEMKESAARVLQEAWMFYKHTRRKESHAARRHQRKLLAAINAFRQVRLKHRK
LREQVNSMVDISKMHMILYDLQQNLSSSHRALEKQIDTLAGKLDALTELLSTALGPRQLP
EPSQQSK
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  Blast E-value cutoff:
BDBM50019903
n/a
NameBDBM50019903
Synonyms:CHEMBL3287208 | US9533999, i-40
TypeSmall organic molecule
Emp. Form.C14H9F4NO4S2
Mol. Mass.395.349
SMILESFc1ccc(CN2c3ccsc3S(=O)(=O)CC2=O)cc1OC(F)(F)F
Structure
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