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TargetGrowth hormone secretagogue receptor type 1
LigandBDBM50440261
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1361892 (CHEMBL3293067)
Ki 6.3±n/a nM
Citation Bhattacharya, SKAndrews, KBeveridge, RCameron, KOChen, CDunn, MFernando, DGao, HHepworth, DJackson, VMKhot, VKong, JKosa, RELapham, KLoria, PMLondregan, ATMcClure, KFOrr, STPatel, JRose, CSaenz, JStock, IAStorer, GVanVolkenburg, MVrieze, DWang, GXiao, JZhang, Y Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate. ACS Med Chem Lett5:474-9 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50440261
n/a
NameBDBM50440261
Synonyms:CHEMBL2426677
TypeSmall organic molecule
Emp. Form.C29H32N4O2
Mol. Mass.468.59
SMILESCOc1ccc(CC(=O)N2CCC3(CN(C3)[C@@H]3CCc4cc(ccc34)-c3ncccn3)CC2)cc1 |r|
Structure
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