Reaction Details |
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Target | Growth hormone secretagogue receptor type 1 |
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Ligand | BDBM50019921 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1361892 (CHEMBL3293067) |
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Ki | 4.6±n/a nM |
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Citation | Bhattacharya, SK; Andrews, K; Beveridge, R; Cameron, KO; Chen, C; Dunn, M; Fernando, D; Gao, H; Hepworth, D; Jackson, VM; Khot, V; Kong, J; Kosa, RE; Lapham, K; Loria, PM; Londregan, AT; McClure, KF; Orr, ST; Patel, J; Rose, C; Saenz, J; Stock, IA; Storer, G; VanVolkenburg, M; Vrieze, D; Wang, G; Xiao, J; Zhang, Y Discovery of PF-5190457, a Potent, Selective, and Orally Bioavailable Ghrelin Receptor Inverse Agonist Clinical Candidate. ACS Med Chem Lett5:474-9 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Growth hormone secretagogue receptor type 1 |
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Name: | Growth hormone secretagogue receptor type 1 |
Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
Type: | Receptor |
Mol. Mass.: | 41334.57 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
Residue: | 366 |
Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM50019921 |
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n/a |
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Name | BDBM50019921 |
Synonyms: | CHEMBL3287213 |
Type | Small organic molecule |
Emp. Form. | C28H30N6OS |
Mol. Mass. | 498.642 |
SMILES | Cc1cn2cc(CC(=O)N3CCC4(CN(C4)[C@@H]4CCc5cc(ccc45)-c4ncccn4)CC3)nc2s1 |r| |
Structure |
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