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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020057 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
| IC50 | 160±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM50020057 | |||
| n/a | |||
| Name | BDBM50020057 | ||
| Synonyms: | CHEMBL3287868 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C32H36N2O4 | ||
| Mol. Mass. | 512.6392 | ||
| SMILES | CCCC1CN(C(=O)Nc2ccccc2)c2ccc(cc2O1)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:31.35,wD:28.31,(21.83,-1.51,;21.06,-2.85,;19.52,-2.85,;18.75,-4.18,;19.52,-5.51,;18.75,-6.85,;19.52,-8.18,;18.75,-9.51,;21.06,-8.18,;21.83,-9.51,;23.37,-9.51,;24.14,-10.85,;23.37,-12.18,;21.83,-12.18,;21.06,-10.85,;17.21,-6.85,;16.44,-8.18,;14.9,-8.18,;14.13,-6.85,;14.9,-5.51,;16.44,-5.51,;17.21,-4.18,;12.59,-6.85,;11.82,-5.51,;10.28,-5.51,;9.51,-6.85,;10.28,-8.18,;11.82,-8.18,;7.97,-6.85,;7.2,-5.51,;5.66,-5.51,;4.89,-6.85,;3.35,-6.85,;2.58,-5.51,;1.04,-5.51,;3.35,-4.18,;5.66,-8.18,;7.2,-8.18,)| | ||
| Structure | 
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