Reaction Details |
| Report a problem with these data |
Target | Diacylglycerol O-acyltransferase 1 |
---|
Ligand | BDBM50020065 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) |
---|
IC50 | 310±n/a nM |
---|
Citation | Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Diacylglycerol O-acyltransferase 1 |
---|
Name: | Diacylglycerol O-acyltransferase 1 |
Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
Type: | Enzyme |
Mol. Mass.: | 56810.61 |
Organism: | Mus musculus (mouse) |
Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. |
Residue: | 498 |
Sequence: | MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVRDAAVSPDLGAGGDAPAPAPAPAHTR
DKDGRTSVGDGYWDLRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKY
GILVDPIQVVSLFLKDPYSWPAPCVIIASNIFVVAAFQIEKRLAVGALTEQMGLLLHVVN
LATIICFPAAVALLVESITPVGSVFALASYSIMFLKLYSYRDVNLWCRQRRVKAKAVSTG
KKVSGAAAQQAVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFT
QLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWFFHSCLNAV
AELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRHGSSKWVARTGVFL
TSAFFHEYLVSVPLRMFRLWAFTAMMAQVPLAWIVGRFFQGNYGNAAVWVTLIIGQPVAV
LMYVHDYYVLNYDAPVGV
|
|
|
BDBM50020065 |
---|
n/a |
---|
Name | BDBM50020065 |
Synonyms: | CHEMBL3287895 |
Type | Small organic molecule |
Emp. Form. | C26H28N4O5 |
Mol. Mass. | 476.5243 |
SMILES | CCC1CN(C(=O)Nc2ccccc2)c2ccc(cc2O1)-c1cnc(OCC(C)(C)C(O)=O)nc1 |
Structure |
|