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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020076 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
| IC50 | 5200±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM50020076 | |||
| n/a | |||
| Name | BDBM50020076 | ||
| Synonyms: | CHEMBL3287880 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H31N3O4 | ||
| Mol. Mass. | 485.5741 | ||
| SMILES | Nc1ccccc1NC(=O)N1CCOc2cc(ccc12)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:29.33,wD:26.29,(2.65,-29.35,;3.42,-28.02,;2.65,-26.68,;3.42,-25.35,;4.96,-25.35,;5.73,-26.68,;4.96,-28.02,;5.73,-29.35,;7.27,-29.35,;8.04,-28.02,;8.04,-30.68,;7.27,-32.02,;8.04,-33.35,;9.58,-33.35,;10.35,-32.02,;11.89,-32.02,;12.66,-30.68,;11.89,-29.35,;10.35,-29.35,;9.58,-30.68,;14.2,-30.68,;14.97,-32.02,;16.51,-32.02,;17.28,-30.68,;16.51,-29.35,;14.97,-29.35,;18.82,-30.68,;19.59,-32.02,;21.13,-32.02,;21.9,-30.68,;23.44,-30.68,;24.21,-32.02,;23.44,-33.35,;25.75,-32.02,;21.13,-29.35,;19.59,-29.35,)| | ||
| Structure | 
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