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TargetDiacylglycerol O-acyltransferase 1
LigandBDBM50020082
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1363771 (CHEMBL3294188)
IC50>10000±n/a nM
Citation Zhou, GZorn, NTing, PAslanian, RLin, MCook, JLachowicz, JLin, ASmith, MHwa, Jvan Heek, MWalker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Diacylglycerol O-acyltransferase 1
Name:Diacylglycerol O-acyltransferase 1
Synonyms:ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase
Type:Protein
Mol. Mass.:55297.82
Organism:Homo sapiens (Human)
Description:O75907
Residue:488
Sequence:
MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
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  Blast E-value cutoff:
BDBM50020082
n/a
NameBDBM50020082
Synonyms:CHEMBL3287871
TypeSmall organic molecule
Emp. Form.C29H31NO5S
Mol. Mass.505.625
SMILESOC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)S(=O)(=O)Cc1ccccc1 |r,wU:7.10,wD:4.3,(29.7,-15.27,;31.04,-16.03,;32.36,-15.24,;31.06,-17.57,;29.73,-18.35,;28.39,-17.59,;27.07,-18.38,;27.09,-19.92,;28.43,-20.67,;29.75,-19.89,;25.76,-20.7,;24.42,-19.94,;23.1,-20.73,;23.12,-22.27,;24.46,-23.02,;25.78,-22.24,;21.79,-23.05,;21.81,-24.59,;20.49,-25.37,;19.15,-24.62,;17.82,-25.4,;16.48,-24.64,;16.47,-23.1,;17.79,-22.32,;19.13,-23.07,;20.45,-22.29,;17.84,-26.93,;16.35,-26.52,;17.44,-28.4,;19.16,-27.72,;19.12,-29.26,;17.78,-30,;17.75,-31.54,;19.06,-32.34,;20.4,-31.6,;20.44,-30.06,)|
Structure
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