Reaction Details | |||
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Target | Diacylglycerol O-acyltransferase 1 | ||
Ligand | BDBM50020079 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
IC50 | >10000±n/a nM | ||
Citation | Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Diacylglycerol O-acyltransferase 1 | |||
Name: | Diacylglycerol O-acyltransferase 1 | ||
Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
Type: | Enzyme | ||
Mol. Mass.: | 56810.61 | ||
Organism: | Mus musculus (mouse) | ||
Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
Residue: | 498 | ||
Sequence: |
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BDBM50020079 | |||
n/a | |||
Name | BDBM50020079 | ||
Synonyms: | CHEMBL3287859 | ||
Type | Small organic molecule | ||
Emp. Form. | C29H30N2O4 | ||
Mol. Mass. | 470.5595 | ||
SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2OCCN(C(=O)Nc3ccccc3)c2c1 |r,wU:7.10,wD:4.3,(28.28,-.1,;26.95,-.87,;26.95,-2.41,;25.61,-.1,;24.28,-.87,;22.95,-.1,;21.61,-.87,;21.61,-2.41,;22.95,-3.18,;24.28,-2.41,;20.28,-3.18,;20.28,-4.72,;18.94,-5.49,;17.61,-4.72,;17.61,-3.18,;18.94,-2.41,;16.28,-5.49,;16.28,-7.03,;14.94,-7.8,;13.61,-7.03,;12.28,-7.8,;10.94,-7.03,;10.94,-5.49,;12.28,-4.72,;12.28,-3.18,;13.61,-2.41,;10.94,-2.41,;10.94,-.87,;9.61,-.1,;9.61,1.44,;10.94,2.21,;12.28,1.44,;12.28,-.1,;13.61,-5.49,;14.94,-4.72,)| | ||
Structure |