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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020081 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM50020081 | |||
| n/a | |||
| Name | BDBM50020081 | ||
| Synonyms: | CHEMBL3287863 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H30N2O5 | ||
| Mol. Mass. | 498.5696 | ||
| SMILES | CC1Oc2cc(ccc2N(C(=O)Nc2ccccc2)C1=O)-c1ccc(cc1)[C@H]1CC[C@H](CC(O)=O)CC1 |r,wU:27.30,wD:30.34,(3,-8.79,;3.77,-7.46,;5.31,-7.46,;6.08,-6.13,;7.62,-6.13,;8.39,-4.79,;7.62,-3.46,;6.08,-3.46,;5.31,-4.79,;3.77,-4.79,;3,-3.46,;3.77,-2.13,;1.46,-3.46,;.69,-2.13,;-.85,-2.13,;-1.62,-.79,;-.85,.54,;.69,.54,;1.46,-.79,;3,-6.13,;1.46,-6.13,;9.93,-4.79,;10.7,-6.13,;12.24,-6.13,;13.01,-4.79,;12.24,-3.46,;10.7,-3.46,;14.55,-4.79,;15.32,-3.46,;16.86,-3.46,;17.63,-4.79,;19.17,-4.79,;19.94,-6.13,;21.48,-6.13,;19.17,-7.46,;16.86,-6.13,;15.32,-6.13,)| | ||
| Structure | 
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