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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50020070 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1363772 (CHEMBL3294189) | ||
| IC50 | 110±n/a nM | ||
| Citation |  Zhou, G; Zorn, N; Ting, P; Aslanian, R; Lin, M; Cook, J; Lachowicz, J; Lin, A; Smith, M; Hwa, J; van Heek, M; Walker, S Development of novel benzomorpholine class of diacylglycerol acyltransferase I inhibitors. ACS Med Chem Lett5:544-9 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM50020070 | |||
| n/a | |||
| Name | BDBM50020070 | ||
| Synonyms: | CHEMBL3287881 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C30H32N2O4 | ||
| Mol. Mass. | 484.5861 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2N(CCOc2c1)C(=O)NCc1ccccc1 |r,wU:7.10,wD:4.3,(20.88,.99,;19.56,.19,;18.21,.93,;19.6,-1.36,;18.29,-2.16,;16.93,-1.42,;15.62,-2.22,;15.66,-3.76,;17.01,-4.5,;18.32,-3.7,;14.34,-4.56,;12.99,-3.82,;11.68,-4.62,;11.71,-6.16,;13.06,-6.9,;14.38,-6.1,;10.4,-6.96,;10.44,-8.5,;9.12,-9.3,;7.77,-8.56,;6.46,-9.36,;5.1,-8.62,;5.07,-7.08,;6.38,-6.28,;7.73,-7.02,;9.05,-6.22,;6.49,-10.9,;7.84,-11.63,;5.18,-11.7,;5.21,-13.23,;3.9,-14.03,;2.55,-13.29,;1.24,-14.09,;1.28,-15.63,;2.63,-16.36,;3.94,-15.56,)| | ||
| Structure | 
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