| Reaction Details |
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 | Report a problem with these data |
| Target | Proteinase-activated receptor 1 |
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| Ligand | BDBM50020146 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364167 (CHEMBL3292644) |
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| Ki | 232±n/a nM |
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| Citation |  Chelliah, MV; Eagen, K; Guo, Z; Chackalamannil, S; Xia, Y; Tsai, H; Greenlee, WJ; Ahn, HS; Kurowski, S; Boykow, G; Hsieh, Y; Chintala, M Himbacine-derived thrombin receptor antagonists: c7-spirocyclic analogues of vorapaxar. ACS Med Chem Lett5:561-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteinase-activated receptor 1 |
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| Name: | Proteinase-activated receptor 1 |
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| Synonyms: | CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1) |
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| Type: | Protein |
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| Mol. Mass.: | 47450.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25116 |
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| Residue: | 425 |
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| Sequence: | MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEE
KNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLN
IMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTA
AFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLK
EQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSS
AVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVS
SISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIY
KKLLT
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| BDBM50020146 |
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| n/a |
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| Name | BDBM50020146 |
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| Synonyms: | CHEMBL3288444 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H29N3O4 |
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| Mol. Mass. | 459.5369 |
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| SMILES | [H][C@@]12C[C@]3([H])C[C@]4(COC(=O)N4)CC[C@@]3([H])[C@H](\C=C\c3ccc(cn3)-c3ccccn3)[C@]1([H])[C@@H](C)OC2=O |r| |
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| Structure | 
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