| Reaction Details |
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 | Report a problem with these data |
| Target | Chloroquine resistance transporter |
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| Ligand | BDBM81939 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364181 (CHEMBL3292896) |
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| IC50 | 33000±n/a nM |
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| Citation |  Deane, KJ; Summers, RL; Lehane, AM; Martin, RE; Barrow, RA Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT. ACS Med Chem Lett5:576-81 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chloroquine resistance transporter |
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| Name: | Chloroquine resistance transporter |
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| Synonyms: | CRT | CRT_PLAFA | PfCRT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48687.29 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_1364181 |
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| Residue: | 424 |
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| Sequence: | MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIF
IYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSK
ERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYH
LYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKI
DILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVEN
CGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAY
YFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDS
IITQ
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| BDBM81939 |
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| n/a |
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| Name | BDBM81939 |
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| Synonyms: | CAS_52-53-9 | NSC_62969 | VERAPAMIL |
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| Type | Small organic molecule |
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| Emp. Form. | C27H38N2O4 |
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| Mol. Mass. | 454.6016 |
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| SMILES | COc1ccc(CCN(C)CCCC(C#N)(C(C)C)c2ccc(OC)c(OC)c2)cc1OC |
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| Structure | 
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