| Reaction Details |
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 | Report a problem with these data |
| Target | Chloroquine resistance transporter |
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| Ligand | BDBM50017696 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364181 (CHEMBL3292896) |
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| IC50 | 85000±n/a nM |
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| Citation |  Deane, KJ; Summers, RL; Lehane, AM; Martin, RE; Barrow, RA Chlorpheniramine Analogues Reverse Chloroquine Resistance in Plasmodium falciparum by Inhibiting PfCRT. ACS Med Chem Lett5:576-81 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chloroquine resistance transporter |
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| Name: | Chloroquine resistance transporter |
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| Synonyms: | CRT | CRT_PLAFA | PfCRT |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48687.29 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_1364181 |
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| Residue: | 424 |
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| Sequence: | MKFASKKNNQKNSSKNDERYRELDNLVQEGNGSRLGGGSCLGKCAHVFKLIFKEIKDNIF
IYILSIIYLSVCVMNKIFAKRTLNKIGNYSFVTSETHNFICMIMFFIVYSLFGNKKGNSK
ERHRSFNLQFFAISMLDACSVILAFIGLTRTTGNIQSFVLQLSIPINMFFCFLILRYRYH
LYNYLGAVIIVVTIALVEMKLSFETQEENSIIFNLVLISALIPVCFSNMTREIVFKKYKI
DILRLNAMVSFFQLFTSCLILPVYTLPFLKQLHLPYNEIWTNIKNGFACLFLGRNTVVEN
CGLGMAKLCDDCDGAWKTFALFSFFNICDNLITSYIIDKFSTMTYTIVSCIQGPAIAIAY
YFKFLAGDVVREPRLLDFVTLFGYLFGSIIYRVGNIILERKKMRNEENEDSEGELTNVDS
IITQ
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| BDBM50017696 |
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| n/a |
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| Name | BDBM50017696 |
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| Synonyms: | (2-dimethylamino-2-methyl)ethyl-N-dibenzoparathiazine | 10-(2-Dimethylaminopropyl)phenothiazine | 10-[2-(dimethylamino)propyl]phenothiazine | CHEMBL643 | N,N,alpha-trimethyl-10H-phenothiazine-10-ethanamine | N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine | PROMETHAZINE | med.21724, Compound 16 | proazamine |
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| Type | Small organic molecule |
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| Emp. Form. | C17H20N2S |
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| Mol. Mass. | 284.419 |
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| SMILES | CC(CN1c2ccccc2Sc2ccccc12)N(C)C |
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| Structure | 
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