Reaction Details |
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Target | Tyrosine-protein kinase TXK |
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Ligand | BDBM50020471 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1361211 (CHEMBL3292443) |
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IC50 | 1.9±n/a nM |
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Citation | Li, X; Zuo, Y; Tang, G; Wang, Y; Zhou, Y; Wang, X; Guo, T; Xia, M; Ding, N; Pan, Z Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem57:5112-28 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase TXK |
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Name: | Tyrosine-protein kinase TXK |
Synonyms: | PTK4 | Protein-tyrosine kinase 4 | RLK | Resting lymphocyte kinase | TXK | TXK_HUMAN | Tyrosine-protein kinase TXK (TXK) |
Type: | Protein |
Mol. Mass.: | 61268.80 |
Organism: | Homo sapiens (Human) |
Description: | P42681 |
Residue: | 527 |
Sequence: | MILSSYNTIQSVFCCCCCCSVQKRQMRTQISLSTDEELPEKYTQRRRPWLSQLSNKKQSN
TGRVQPSKRKPLPPLPPSEVAEEKIQVKALYDFLPREPCNLALRRAEEYLILEKYNPHWW
KARDRLGNEGLIPSNYVTENKITNLEIYEWYHRNITRNQAEHLLRQESKEGAFIVRDSRH
LGSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWYHQHNAAGLMT
RLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEWRSHIQVAIKA
INEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKPLYIVTEFMENGCLLNYLRENKG
KLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEY
VSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAIS
EGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEIAETW
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BDBM50020471 |
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n/a |
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Name | BDBM50020471 |
Synonyms: | CHEMBL3290142 |
Type | Small organic molecule |
Emp. Form. | C29H23F3N6O3 |
Mol. Mass. | 560.5265 |
SMILES | Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(Nc2cccc(NC(=O)C=C)c2)nc1 |
Structure |
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