| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 5-lipoxygenase |
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| Ligand | BDBM50020584 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1361578 |
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| IC50 | 13±n/a nM |
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| Citation |  Koeberle A; Muņoz E; Appendino GB; Minassi A; Pace S; Rossi A; Weinigel C; Barz D; Sautebin L; Caprioglio D; Collado JA; Werz O SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. J Med Chem 57:5638-48 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arachidonate 5-lipoxygenase |
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| Name: | Arachidonate 5-lipoxygenase |
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| Synonyms: | 5-LO | 5-Lipo-oxygenase (5-LOX) | 5-Lipoxygenase (5-LO) | 5-Lipoxygenase (LOX) | 5-Lipoygenase | ALOX5 | LOG5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 77972.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant protein was purified from E. coli lysate. After ammonium sulfate precipitation and subsequent steps, the supernatant (S100) was used for 5-LO activity assay.
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| Residue: | 674 |
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| Sequence: | MPSYTVTVATGSQWFAGTDDYIYLSLVGSAGCSEKHLLDKPFYNDFERGAVDSYDVTVDE
ELGEIQLVRIEKRKYWLNDDWYLKYITLKTPHGDYIEFPCYRWITGDVEVVLRDGRAKLA
RDDQIHILKQHRRKELETRQKQYRWMEWNPGFPLSIDAKCHKDLPRDIQFDSEKGVDFVL
NYSKAMENLFINRFMHMFQSSWNDFADFEKIFVKISNTISERVMNHWQEDLMFGYQFLNG
CNPVLIRRCTELPEKLPVTTEMVECSLERQLSLEQEVQQGNIFIVDFELLDGIDANKTDP
CTLQFLAAPICLLYKNLANKIVPIAIQLNQIPGDENPIFLPSDAKYDWLLAKIWVRSSDF
HVHQTITHLLRTHLVSEVFGIAMYRQLPAVHPIFKLLVAHVRFTIAINTKAREQLICECG
LFDKANATGGGGHVQMVQRAMKDLTYASLCFPEAIKARGMESKEDIPYYFYRDDGLLVWE
AIRTFTAEVVDIYYEGDQVVEEDPELQDFVNDVYVYGMRGRKSSGFPKSVKSREQLSEYL
TVVIFTASAQHAAVNFGQYDWCSWIPNAPPTMRAPPPTAKGVVTIEQIVDTLPDRGRSCW
HLGAVWALSQFQENELFLGMYPEEHFIEKPVKEAMARFRKNLEAIVSVIAERNKKKQLPY
YYLSPDRIPNSVAI
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| BDBM50020584 |
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| n/a |
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| Name | BDBM50020584 |
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| Synonyms: | CHEMBL2413471 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18N2O4 |
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| Mol. Mass. | 338.3572 |
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| SMILES | COc1cc(\C=C\c2cc([nH]n2)-c2ccc(O)c(OC)c2)ccc1O |
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| Structure | 
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