Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50020905 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1364645 (CHEMBL3291778) |
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IC50 | 50±n/a nM |
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Citation | Chen, F; Chai, H; Su, MB; Zhang, YM; Li, J; Xie, X; Nan, FJ Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors. ACS Med Chem Lett5:628-33 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50020905 |
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n/a |
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Name | BDBM50020905 |
Synonyms: | CHEMBL3287263 | US9216962, CFH461 |
Type | Small organic molecule |
Emp. Form. | C21H24N4O4S2 |
Mol. Mass. | 460.57 |
SMILES | ONC(=O)CCCCNC(=O)c1nc(sc1CCOCc1ccccc1)-c1nccs1 |
Structure |
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