| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50020905 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1364647 (CHEMBL3291780) |
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| IC50 | 160±n/a nM |
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| Citation |  Chen, F; Chai, H; Su, MB; Zhang, YM; Li, J; Xie, X; Nan, FJ Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors. ACS Med Chem Lett5:628-33 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50020905 |
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| n/a |
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| Name | BDBM50020905 |
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| Synonyms: | CHEMBL3287263 | US9216962, CFH461 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N4O4S2 |
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| Mol. Mass. | 460.57 |
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| SMILES | ONC(=O)CCCCNC(=O)c1nc(sc1CCOCc1ccccc1)-c1nccs1 |
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| Structure | 
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