| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM22032 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1365856 (CHEMBL3296477) |
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| Ki | 0.400000±n/a nM |
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| Citation |  Denora, N; Margiotta, N; Laquintana, V; Lopedota, A; Cutrignelli, A; Losacco, M; Franco, M; Natile, G Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand. ACS Med Chem Lett5:685-9 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM22032 |
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| n/a |
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| Name | BDBM22032 |
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| Synonyms: | 1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)isoquinoline-3-carboxamide | CHEMBL15313 | N-(butan-2-yl)-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide | PK 11195 | PK-11195 | PK11195 | RP 52028 | [3H]PK 11195 |
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| Type | radiolabeled ligand |
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| Emp. Form. | C21H21ClN2O |
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| Mol. Mass. | 352.857 |
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| SMILES | CCC(C)N(C)C(=O)c1cc2ccccc2c(n1)-c1ccccc1Cl |
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| Structure | 
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