Reaction Details |
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Target | Translocator protein |
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Ligand | BDBM50408728 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1365856 (CHEMBL3296477) |
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Ki | 1.6±n/a nM |
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Citation | Denora, N; Margiotta, N; Laquintana, V; Lopedota, A; Cutrignelli, A; Losacco, M; Franco, M; Natile, G Synthesis, Characterization, and in Vitro Evaluation of a New TSPO-Selective Bifunctional Chelate Ligand. ACS Med Chem Lett5:685-9 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Translocator protein |
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Name: | Translocator protein |
Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
Type: | Mitochondrion membrane protein |
Mol. Mass.: | 18945.84 |
Organism: | Rattus norvegicus (rat) |
Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
Residue: | 169 |
Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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BDBM50408728 |
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n/a |
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Name | BDBM50408728 |
Synonyms: | CHEMBL339816 |
Type | Small organic molecule |
Emp. Form. | C21H25ClN4O |
Mol. Mass. | 384.902 |
SMILES | CCCN(CCC)C(=O)Cc1c(nc2c(N)cccn12)-c1ccc(Cl)cc1 |
Structure |
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