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TargetFatty-acid amide hydrolase 1 [30-579]
LigandBDBM50350538
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1366316 (CHEMBL3295962)
IC50 11±n/a nM
Citation Chobanian, HRGuo, YLiu, PChioda, MDFung, SLanza, TJChang, LBakshi, RKDellureficio, JPHong, QMcLaughlin, MBelyk, KMKrska, SWMakarewicz, AKMartel, EJLeone, JFFrey, LKaranam, BMadeira, MAlvaro, RShuman, JSalituro, GTerebetski, JLJochnowitz, NMistry, SMcGowan, EHajdu, RRosenbach, MAbbadie, CAlexander, JPShiao, LLSullivan, KMNargund, RPWyvratt, MJLin, LSDeVita, RJ Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain. ACS Med Chem Lett5:717-21 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Fatty-acid amide hydrolase 1 [30-579]
Name:Fatty-acid amide hydrolase 1 [30-579]
Synonyms:Anandamide amidohydrolase 1 | FAAH1_RAT | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty Acid Amide Hydrolic, FAAH | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Fatty-acid amide hydrolase 1 (FAAH) | Fatty-acid amide hydrolase 1 (aa 30-579) | Oleamide hydrolase 1
Type:Single-pass membrane protein; homodimer
Mol. Mass.:60474.00
Organism:Rattus norvegicus (rat)
Description:P97612 (aa 30-579)
Residue:550
Sequence:
RWTGRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSG
ELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKG
HDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWK
SSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGC
VYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGY
YETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFL
QNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQH
EIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPV
TTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVE
QLMTPQKQPS
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BDBM50350538
n/a
NameBDBM50350538
Synonyms:CHEMBL1812717
TypeSmall organic molecule
Emp. Form.C22H17ClFN3O2S
Mol. Mass.441.906
SMILESCC(C)(O)c1ccc(cn1)-c1nc(oc1Sc1ccc(Cl)cn1)-c1ccc(F)cc1
Structure
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