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TargetHistamine H4 receptor
LigandBDBM50021536
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1364324
Ki 203±n/a nM
Citation Lazewska DWiecek MNer JKaminska KKottke TSchwed JSZygmunt MKarcz TOlejarz AKuder KLatacz GGrosicki MSapa JKarolak-Wojciechowska JStark HKiec-Kononowicz K Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands. Eur J Med Chem 83:534-46 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPRv53 | HH4R | HISTAMINE H4 | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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BDBM50021536
n/a
NameBDBM50021536
Synonyms:CHEMBL3290576
TypeSmall organic molecule
Emp. Form.C14H17ClN6
Mol. Mass.304.778
SMILESCN1CCN(CC1)c1nc(N)nc(n1)-c1ccc(Cl)cc1
Structure
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