| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lyn |
|---|
| Ligand | BDBM50021618 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1368031 (CHEMBL3300958) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Casuscelli, F; Ardini, E; Avanzi, N; Casale, E; Cervi, G; D'Anello, M; Donati, D; Faiardi, D; Ferguson, RD; Fogliatto, G; Galvani, A; Marsiglio, A; Mirizzi, DG; Montemartini, M; Orrenius, C; Papeo, G; Piutti, C; Salom, B; Felder, ER Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases. Bioorg Med Chem21:7364-80 (2013) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Lyn |
|---|
| Name: | Tyrosine-protein kinase Lyn |
|---|
| Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58575.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07948 |
|---|
| Residue: | 512 |
|---|
| Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
|
|
|
|---|
| BDBM50021618 |
|---|
| n/a |
|---|
| Name | BDBM50021618 |
|---|
| Synonyms: | CHEMBL3297762 | US9145418, 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H38ClN5O2 |
|---|
| Mol. Mass. | 512.087 |
|---|
| SMILES | CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
