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TargetSerine/threonine-protein kinase pim-1
LigandBDBM50021654
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1368150 (CHEMBL3301295)
IC50 233±n/a nM
Citation Casuscelli, FArdini, EAvanzi, NCasale, ECervi, GD'Anello, MDonati, DFaiardi, DFerguson, RDFogliatto, GGalvani, AMarsiglio, AMirizzi, DGMontemartini, MOrrenius, CPapeo, GPiutti, CSalom, BFelder, ER Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases. Bioorg Med Chem21:7364-80 (2013) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase pim-1
Synonyms:PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50021654
n/a
NameBDBM50021654
Synonyms:CHEMBL3297760
TypeSmall organic molecule
Emp. Form.C26H27FN4O2
Mol. Mass.446.5166
SMILESCN1CCN([C@H](C1)c1ccccc1)C(=O)C[C@H]1CNC(=O)c2cc(cn12)-c1cccc(F)c1 |r|
Structure
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