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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Ribosomal protein S6 kinase alpha-3 | ||
| Ligand | BDBM50021671 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1368329 (CHEMBL868675) | ||
| IC50 | 490±n/a nM | ||
| Citation |  Costales, A; Mathur, M; Ramurthy, S; Lan, J; Subramanian, S; Jain, R; Atallah, G; Setti, L; Lindvall, M; Appleton, BA; Ornelas, E; Feucht, P; Warne, B; Doyle, L; Basham, SE; Aronchik, I; Jefferson, AB; Shafer, CM 2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors. Bioorg Med Chem Lett24:1592-6 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Ribosomal protein S6 kinase alpha-3 | |||
| Name: | Ribosomal protein S6 kinase alpha-3 | ||
| Synonyms: | 90 kDa ribosomal protein S6 kinase 3 | ISPK-1 | ISPK1 | KS6A3_HUMAN | MAP kinase-activated protein kinase 1b | MAPKAPK1B | RPS6KA3 | RPS6KA3(Kin.Dom.1 - N-terminal) | RSK2 | Ribosomal S6 kinase 2 (RSK2) | Ribosomal protein S6 kinase | Ribosomal protein S6 kinase alpha-1/alpha-3 | Ribosomal protein S6 kinase alpha-3 (RSK2) | Ribosomal protein S6 kinase alpha-3 (RSK3) | S6K-alpha 3 | insulin-stimulated protein kinase 1 | p90 ribosomal s6 kinase (RSK2) | p90-RSK 3 | p90RSK | pp90RSK2 | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 83740.03 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | The human RSK2 sequence differed from the Genbank entry NM_004586 at one residue, V45G. The protein was cloned and purified from baculovirus expression system. | ||
| Residue: | 740 | ||
| Sequence: |
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| BDBM50021671 | |||
| n/a | |||
| Name | BDBM50021671 | ||
| Synonyms: | CHEMBL3298042 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H23FN2O5 | ||
| Mol. Mass. | 438.4482 | ||
| SMILES | CCOc1cccc(F)c1-c1cccc2nc(Nc3cc(OC)c(OC)c(OC)c3)oc12 |(22.28,-22.22,;20.95,-23,;19.61,-22.24,;18.28,-23.01,;18.29,-24.55,;16.95,-25.33,;15.61,-24.55,;15.61,-23.01,;14.28,-22.24,;16.95,-22.25,;16.94,-20.71,;18.28,-19.93,;18.27,-18.38,;16.94,-17.62,;15.61,-18.39,;14.15,-17.92,;13.24,-19.16,;11.7,-19.16,;10.93,-20.49,;11.7,-21.82,;10.93,-23.15,;11.7,-24.48,;10.94,-25.82,;9.38,-23.15,;8.61,-24.48,;7.07,-24.48,;8.61,-21.81,;7.07,-21.81,;6.31,-20.48,;9.39,-20.48,;14.14,-20.4,;15.61,-19.93,)| | ||
| Structure | 
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