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TargetRibosomal protein S6 kinase alpha-3
LigandBDBM50021676
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1368329 (CHEMBL868675)
IC50 970±n/a nM
Citation Costales, AMathur, MRamurthy, SLan, JSubramanian, SJain, RAtallah, GSetti, LLindvall, MAppleton, BAOrnelas, EFeucht, PWarne, BDoyle, LBasham, SEAronchik, IJefferson, ABShafer, CM 2-Amino-7-substituted benzoxazole analogs as potent RSK2 inhibitors. Bioorg Med Chem Lett24:1592-6 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Ribosomal protein S6 kinase alpha-3
Name:Ribosomal protein S6 kinase alpha-3
Synonyms:90 kDa ribosomal protein S6 kinase 3 | ISPK-1 | ISPK1 | KS6A3_HUMAN | MAP kinase-activated protein kinase 1b | MAPKAPK1B | RPS6KA3 | RPS6KA3(Kin.Dom.1 - N-terminal) | RSK2 | Ribosomal S6 kinase 2 (RSK2) | Ribosomal protein S6 kinase | Ribosomal protein S6 kinase alpha-1/alpha-3 | Ribosomal protein S6 kinase alpha-3 (RSK2) | Ribosomal protein S6 kinase alpha-3 (RSK3) | S6K-alpha 3 | insulin-stimulated protein kinase 1 | p90 ribosomal s6 kinase (RSK2) | p90-RSK 3 | p90RSK | pp90RSK2
Type:Serine/threonine-protein kinase
Mol. Mass.:83740.03
Organism:Homo sapiens (Human)
Description:The human RSK2 sequence differed from the Genbank entry NM_004586 at one residue, V45G. The protein was cloned and purified from baculovirus expression system.
Residue:740
Sequence:
MPLAQLADPWQKMAVESPSDSAENGQQIMDEPMGEEEINPQTEEVSIKEIAITHHVKEGH
EKADPSQFELLKVLGQGSFGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERD
ILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALA
LDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVV
NRRGHTQSADWWSFGVLMFEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLR
MLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPATGRPEDTFYFDPE
FTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTD
GYEVKEDIGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLK
DVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDL
KPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACD
IWSLGVLLYTMLTGYTPFANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKML
HVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSALNRNQSPVLEP
VGRSTLAQRRGIKKITSTAL
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  Blast E-value cutoff:
BDBM50021676
n/a
NameBDBM50021676
Synonyms:CHEMBL3298043
TypeSmall organic molecule
Emp. Form.C25H25FN2O5
Mol. Mass.452.4748
SMILESCOc1cc(Nc2nc3cccc(-c4c(F)cccc4OC(C)C)c3o2)cc(OC)c1OC |(10.96,-25.92,;11.73,-24.58,;10.95,-23.25,;11.72,-21.92,;10.95,-20.59,;11.72,-19.26,;13.26,-19.26,;14.17,-18.02,;15.63,-18.49,;16.96,-17.72,;18.29,-18.48,;18.3,-20.03,;16.96,-20.81,;16.97,-22.35,;15.64,-23.11,;14.3,-22.34,;15.64,-24.65,;16.97,-25.43,;18.31,-24.65,;18.3,-23.11,;19.63,-22.34,;20.97,-23.1,;22.3,-22.32,;20.98,-24.64,;15.63,-20.03,;14.16,-20.51,;9.41,-20.58,;8.64,-21.91,;7.1,-21.91,;6.33,-20.58,;9.41,-23.25,;8.64,-24.58,;7.1,-24.58,)|
Structure
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