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TargetCyclin-dependent kinase 2
LigandBDBM50021718
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1368656
IC50 10.0±n/a nM
Citation Blake, JFGaudino, JJDe Meese, JMohr, PChicarelli, MTian, HGarrey, RThomas, ASiedem, CSWelch, MBKolakowski, GKaus, RBurkard, MMartinson, MChen, HDean, BDudley, DAGould, SEPacheco, PShahidi-Latham, SWang, WWest, KYin, JMoffat, JSchwarz, JB Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2. Bioorg Med Chem Lett24:2635-9 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 2
Name:Cyclin-dependent kinase 2
Synonyms:CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:Enzyme Subunit
Mol. Mass.:33938.17
Organism:Homo sapiens (Human)
Description:P24941
Residue:298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50021718
n/a
NameBDBM50021718
Synonyms:CHEMBL3298678
TypeSmall organic molecule
Emp. Form.C21H25ClFN5O3
Mol. Mass.449.906
SMILESOC[C@@H](NC(=O)N1CCc2cnc(NC3CCOCC3)nc2C1)c1ccc(Cl)c(F)c1 |r|
Structure
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