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TargetMitogen-activated protein kinase 1
LigandBDBM50021743
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1368652
IC50 4.0±n/a nM
Citation Blake, JFGaudino, JJDe Meese, JMohr, PChicarelli, MTian, HGarrey, RThomas, ASiedem, CSWelch, MBKolakowski, GKaus, RBurkard, MMartinson, MChen, HDean, BDudley, DAGould, SEPacheco, PShahidi-Latham, SWang, WWest, KYin, JMoffat, JSchwarz, JB Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine inhibitors of Erk2. Bioorg Med Chem Lett24:2635-9 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM50021743
n/a
NameBDBM50021743
Synonyms:CHEMBL3298307
TypeSmall organic molecule
Emp. Form.C21H25ClFN5O2
Mol. Mass.433.907
SMILESOC[C@@H](NC(=O)N1CCc2cnc(NC3CCCC3)nc2C1)c1ccc(F)c(Cl)c1 |r|
Structure
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