| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Chitinase |
|---|
| Ligand | BDBM50022892 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1369100 (CHEMBL3300321) |
|---|
| IC50 | 370±n/a nM |
|---|
| Citation |  Gooyit, M; Tricoche, N; Lustigman, S; Janda, KD Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting. J Med Chem57:5792-9 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Chitinase |
|---|
| Name: | Chitinase |
|---|
| Synonyms: | n/a |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55694.80 |
|---|
| Organism: | Onchocerca volvulus |
|---|
| Description: | ChEMBL_1369100 |
|---|
| Residue: | 497 |
|---|
| Sequence: | MRIGAMLIPFIILGNAIIAYGYVRGCYYTNWAQYRQGEGKFLPEDIPKGLCTHILYAFAK
VDQSGTSLPFEWNDEDTNWSKGMYSRVTKLKENDPEMKILLSYGGYNFGSSTFTAIRNRA
EKRKHFIKSAIAFLRKNKFDGFDFDWEYPIGMAQEYAKLVNEMKVAFVEEAKKSDSEQLL
LTAAVSAGKHTIDQSYNVQSLGENFDLLSLMSYDFHGSWEMNVDLHAKLHPTKGETSGTG
IFNTEFAANYWLSKGMPKQKIIIGIPTYGRGWTLRDSSKTTIGAEGISPSSPSTTNPAGG
TAAYWEICKYLKEGGKETIDEQGVGACMVQGSQWYGYDNEETIRMKMRWLKEKGYGGAFI
WTLDFDDFKGTSCGEGPYPLLSAINHELKGEATATTRSLRTTITQSSTIGSTKFETTTTA
SEITKNNKIKTTTIAVEPTGESSDIKCPESFGLFRHPNDCHLFIHCAHDHPYVKLCPPNT
FFNDKIKVCDHFGECDE
|
|
|
|---|
| BDBM50022892 |
|---|
| n/a |
|---|
| Name | BDBM50022892 |
|---|
| Synonyms: | CHEMBL3298112 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H12ClI2NO2 |
|---|
| Mol. Mass. | 575.566 |
|---|
| SMILES | Oc1c(I)cc(I)cc1C(=O)Nc1ccc(cc1)-c1ccc(Cl)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
