Reaction Details |
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Target | Aurora kinase A |
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Ligand | BDBM50015269 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1369125 |
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Ki | 870±n/a nM |
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Citation | Burch, JD; Lau, K; Barker, JJ; Brookfield, F; Chen, Y; Chen, Y; Eigenbrot, C; Ellebrandt, C; Ismaili, MH; Johnson, A; Kordt, D; MacKinnon, CH; McEwan, PA; Ortwine, DF; Stein, DB; Wang, X; Winkler, D; Yuen, PW; Zhang, Y; Zarrin, AA; Pei, Z Property- and structure-guided discovery of a tetrahydroindazole series of interleukin-2 inducible T-cell kinase inhibitors. J Med Chem57:5714-27 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase A |
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Name: | Aurora kinase A |
Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45830.98 |
Organism: | Homo sapiens (Human) |
Description: | O14965 |
Residue: | 403 |
Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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BDBM50015269 |
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n/a |
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Name | BDBM50015269 |
Synonyms: | CHEMBL3262780 |
Type | Small organic molecule |
Emp. Form. | C19H14N6O |
Mol. Mass. | 342.3541 |
SMILES | O=C(Nc1cnn(Cc2cccc(c2)C#N)c1)c1n[nH]c2ccccc12 |
Structure |
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