Reaction Details |
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Target | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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Ligand | BDBM50322358 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1459633 (CHEMBL3369890) |
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IC50 | 15±n/a nM |
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Citation | Ferla, S; Aboraia, AS; Brancale, A; Pepper, CJ; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. J Med Chem57:7702-15 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
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Name: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial |
Synonyms: | 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | CP24A_HUMAN | CYP24 | CYP24A1 | Cytochrome P450 24A1 |
Type: | Protein |
Mol. Mass.: | 58889.66 |
Organism: | Homo sapiens (Human) |
Description: | Q07973 |
Residue: | 514 |
Sequence: | MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPG
PTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYR
TESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKIN
EVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIM
AIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSAD
FLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVL
PENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQ
VLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIV
RKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
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BDBM50322358 |
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n/a |
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Name | BDBM50322358 |
Synonyms: | 4'-Chloro-biphenyl-4-carboxylic acid((R)-2-imidazol-1-yl-2-phenyl-ethyl)-amide | CHEMBL1170908 |
Type | Small organic molecule |
Emp. Form. | C24H20ClN3O |
Mol. Mass. | 401.888 |
SMILES | Clc1ccc(cc1)-c1ccc(cc1)C(=O)NC[C@@H](c1ccccc1)n1ccnc1 |r| |
Structure |
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