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Target25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
LigandBDBM50023347
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1459634 (CHEMBL3369891)
IC50 240±n/a nM
Citation Ferla, SAboraia, ASBrancale, APepper, CJZhu, JOchalek, JTDeLuca, HFSimons, C Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. J Med Chem57:7702-15 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Name:25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial
Synonyms:25-OHD-1 alpha-hydroxylase | 25-hydroxyvitamin D(3) 1-alpha-hydroxylase | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_MOUSE | Calcidiol 1-monooxygenase | Cyp27b | Cyp27b | Cyp27b1 | Cyp40 | Cytochrome P450 subfamily XXVIIB polypeptide 1 | Cytochrome P450C1 alpha | Cytochrome P450VD1-alpha | Cytochrome p450 27B1 | VD3 1A hydroxylase
Type:PROTEIN
Mol. Mass.:56238.51
Organism:Mus musculus
Description:ChEMBL_109473
Residue:507
Sequence:
MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSR
LHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRH
QRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLP
GLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPN
WLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFRE
KVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHG
TALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQ
FPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPE
PGALPIKPMTRTVLVPERSINLQFVDR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50023347
n/a
NameBDBM50023347
Synonyms:CHEMBL3329768
TypeSmall organic molecule
Emp. Form.C27H25N3O2
Mol. Mass.423.5063
SMILESCOc1ccc(\C=C\c2ccc(cc2)C(=O)NCC(c2ccccc2)n2ccnc2)cc1
Structure
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