| Reaction Details |
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 | Report a problem with these data |
| Target | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Ligand | BDBM50023360 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1459634 (CHEMBL3369891) |
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| IC50 | 230±n/a nM |
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| Citation |  Ferla, S; Aboraia, AS; Brancale, A; Pepper, CJ; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation. J Med Chem57:7702-15 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Name: | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial |
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| Synonyms: | 25-OHD-1 alpha-hydroxylase | 25-hydroxyvitamin D(3) 1-alpha-hydroxylase | 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial | CP27B_MOUSE | Calcidiol 1-monooxygenase | Cyp27b | Cyp27b | Cyp27b1 | Cyp40 | Cytochrome P450 subfamily XXVIIB polypeptide 1 | Cytochrome P450C1 alpha | Cytochrome P450VD1-alpha | Cytochrome p450 27B1 | VD3 1A hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56238.51 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_109473 |
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| Residue: | 507 |
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| Sequence: | MTQAVKLASRVFHRIHLPLQLDASLGSRGSESVLRSLSDIPGPSTLSFLAELFCKGGLSR
LHELQVHGAARYGPIWSGSFGTLRTVYVADPTLVEQLLRQESHCPERCSFSSWAEHRRRH
QRACGLLTADGEEWQRLRSLLAPLLLRPQAAAGYAGTLDNVVRDLVRRLRRQRGRGSGLP
GLVLDVAGEFYKFGLESIGAVLLGSRLGCLEAEVPPDTETFIHAVGSVFVSTLLTMAMPN
WLHHLIPGPWARLCRDWDQMFAFAQRHVELREGEAAMRNQGKPEEDMPSGHHLTHFLFRE
KVSVQSIVGNVTELLLAGVDTVSNTLSWTLYELSRHPDVQTALHSEITAGTRGSCAHPHG
TALSQLPLLKAVIKEVLRLYPVVPGNSRVPDRDIRVGNYVIPQDTLVSLCHYATSRDPTQ
FPDPNSFNPARWLGEGPTPHPFASLPFGFGKRSCIGRRLAELELQMALSQILTHFEVLPE
PGALPIKPMTRTVLVPERSINLQFVDR
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| BDBM50023360 |
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| n/a |
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| Name | BDBM50023360 |
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| Synonyms: | CHEMBL3329779 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H28N2O |
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| Mol. Mass. | 360.4919 |
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| SMILES | CC(C)(C)C(=O)C(Cc1ccc(CCc2ccccc2)cc1)n1ccnc1 |
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| Structure | 
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